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<!DOCTYPE pkgmetadata SYSTEM "http://www.gentoo.org/dtd/metadata.dtd">
<pkgmetadata>
	<longdescription>
		Rank-Based Compositional Analysis using Log-Linear Models for
		Microbiome Data with Zero Cells // Provides rank-based
		compositional differential abundance analysis for microbiome
		count data with zero cells using the compositional accelerated
		failure time model of Satten, Li and Zhao (2025) "CAFT: A
		Compositional Log-Linear Model for Microbiome Data with Zero
		Cells" doi:10.1101/2025.11.26.690468. Zero counts are treated
		as censored observations below sample-specific detection
		limits, avoiding the use of pseudocounts. The package
		implements estimation and hypothesis testing procedures for
		assessing associations between microbial taxa and covariates
		while accounting for the compositional structure of sequencing
		count data. It supports taxon-level differential abundance
		analysis, estimation of regression effects under censoring
		induced by detection limits, and inference based on rank-based
		methods that remain applicable in the presence of excess zeros.
		Functions are provided for model fitting, significance testing,
		extraction of effect estimates, and summarization of results
		across taxa. The package also provides optional bootstrap
		calibration of taxon-level p-values for sensitivity analysis in
		small-taxon settings.
	</longdescription>
</pkgmetadata>
