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<!DOCTYPE pkgmetadata SYSTEM "http://www.gentoo.org/dtd/metadata.dtd">
<pkgmetadata>
	<longdescription>
		Discovery of Candidate Disease Genes Using Trans-Regulatory
		Effects // Implements the DANDELION method for prioritizing
		candidate disease-related proximal genes by integrating trans-
		regulatory association p-values and gene-level trait
		association p-values. The statistical testing framework builds
		on the divide-aggregate composite-null test described by Liu et
		al. (2022) doi:10.1080/01621459.2021.1914634. The biological
		application and SNP/gene-based prioritization workflow are
		motivated by Salamone et al. (under review), "Leveraging trans-
		gene regulation prioritizes central genes and pathways in
		asthma". The package provides functions for identifying distal-
		proximal gene pairs, organizing significant pairs into genomic
		loci, and visualizing resulting gene networks.
	</longdescription>
</pkgmetadata>
