Relationship-Informed Pedigree and Variant Scoring // Comparative evaluation of families and candidate variants in rare-variant association studies. The package can be used for two methodologically overlapping but distinct purposes. First, the prior to any genetic or genomic evaluation, evaluation of relative detection power of pedigrees, can direct recruitment efforts by showing which individuals not yet sampled would be the most meaningful additions to a study. Second, after sequencing and analysis, variants based on association with disease status and familial relationships of individuals, aids in variant prioritization. Methodology is described in Nugent (2025) doi:10.1101/2025.10.06.25337426.