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<!DOCTYPE pkgmetadata SYSTEM "http://www.gentoo.org/dtd/metadata.dtd">
<pkgmetadata>
	<longdescription>
		'NetSurvProx': Network-Based Survival Analysis via Proximal
		Methods // Introduces a novel network-constrained survival
		analysis framework for variable selection and parameter
		estimation in penalized survival models with convex penalties.
		The package extends two classical survival models, the Cox
		Proportional Hazards (PH) model and the Accelerated Failure
		Time (AFT) model, by incorporating prior biological knowledge
		from curated interaction networks (e.g., KEGG) into a double-
		penalty framework. The first penalty enforces variable
		selection through a LASSO penalty, while the second preserves
		gene-gene correlations by incorporating Laplacian-based
		constraints, ensuring that biologically relevant network
		structures are maintained. Using censored survival data, the
		method enables the identification of predictive biomarkers and
		pathways with potential relevance for target therapies. Model
		estimation is performed via proximal optimization algorithms
		combined with cross-validation for reliable tuning. To enhance
		interpretability, dedicated utility functions are implemented
		to consolidate results, yielding biologically coherent insights
		that can support personalized medicine and contribute to
		improved patient outcomes.
	</longdescription>
</pkgmetadata>
