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<!DOCTYPE pkgmetadata SYSTEM "http://www.gentoo.org/dtd/metadata.dtd">
<pkgmetadata>
	<longdescription>
		Regional Consistency Probability for Single-Arm Multi-Regional
		Clinical Trials // Provides functions to calculate and
		visualise the Regional Consistency Probability (RCP) for
		single-arm multi-regional clinical trials (MRCTs) using the
		Effect Retention Approach (ERA). Six endpoint types are
		supported: continuous, binary, count (negative binomial), time-
		to-event via hazard ratio, milestone survival, and restricted
		mean survival time (RMST). For each endpoint, both a closed-
		form (or semi-analytical) solution and a Monte Carlo simulation
		approach are implemented. Two consistency evaluation methods
		are available: Method 1 (effect retention in Region 1 relative
		to the overall population) and Method 2 (simultaneous positive
		effect across all regions). Plotting functions generate faceted
		visualisations of RCP as a function of the regional allocation
		proportion, overlaying formula and simulation results for
		direct comparison. The methodology follows the Japanese MHLW
		guidelines for MRCTs. Abbreviations used: RCP (Regional
		Consistency Probability), MRCT (Multi-Regional Clinical Trial),
		RMST (Restricted Mean Survival Time), MHLW (Ministry of Health,
		Labour and Welfare).
	</longdescription>
</pkgmetadata>
