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<!DOCTYPE pkgmetadata SYSTEM "http://www.gentoo.org/dtd/metadata.dtd">
<pkgmetadata>
	<longdescription>
		Exploratory Subgroup Identification in Clinical Trials with
		Survival Endpoints // Implements statistical methods for
		exploratory subgroup identification in clinical trials with
		survival endpoints. Provides tools for identifying patient
		subgroups with differential treatment effects using machine
		learning approaches including Generalized Random Forests (GRF),
		LASSO regularization, and exhaustive combinatorial search
		algorithms. Features bootstrap bias correction using
		infinitesimal jackknife methods to address selection bias in
		post-hoc analyses. Designed for clinical researchers conducting
		exploratory subgroup analyses in randomized controlled trials,
		particularly for multi-regional clinical trials (MRCT)
		requiring regional consistency evaluation. Supports both
		accelerated failure time (AFT) and Cox proportional hazards
		models with comprehensive diagnostic and visualization tools.
		Methods are described in Len et al. (2024)
		doi:10.1002/sim.10163.
	</longdescription>
</pkgmetadata>
