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<!DOCTYPE pkgmetadata SYSTEM "http://www.gentoo.org/dtd/metadata.dtd">
<pkgmetadata>
	<longdescription>
		Sample Size and Simulation for Negative Binomial Outcomes //
		Provides tools for planning and simulating recurrent event
		trials with overdispersed count endpoints analyzed using
		negative binomial (or Poisson) rate models. Implements sample
		size and power calculations for fixed designs with variable
		accrual, dropout, maximum follow-up, and event gaps, including
		methods of Zhu and Lakkis (2014) doi:10.1002/sim.5947 and
		Friede and Schmidli (2010) doi:10.3414/ME09-02-0060 as well as
		extensions for score-test sizing and gaps between events.
		Supports group sequential monitoring by building on the
		'gsDesign' package. Includes recurrent-event simulation
		utilities (including seasonal rates), interim data truncation,
		Wald and score-test inference for rate ratios, and information
		estimation and sample size re-estimation with or without
		treatment-group labels.
	</longdescription>
</pkgmetadata>
