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<!DOCTYPE pkgmetadata SYSTEM "http://www.gentoo.org/dtd/metadata.dtd">
<pkgmetadata>
	<longdescription>
		Fast Bayesian Optimal Interval Design for Phase I Dose-Finding
		Trials // Conducting Bayesian Optimal Interval (BOIN) design
		for phase I dose-finding trials. 'simFastBOIN' provides
		functions for pre-computing decision tables, conducting trial
		simulations, and evaluating operating characteristics. The
		package uses vectorized operations and the Iso::pava() function
		for isotonic regression to achieve efficient performance while
		maintaining full compatibility with BOIN methodology. Version
		1.3.2 adds p_saf and p_tox parameters for customizable safety
		and toxicity thresholds. Version 1.3.1 fixes Date field.
		Version 1.2.1 adds comprehensive 'roxygen2' documentation and
		enhanced print formatting with flexible table output options.
		Version 1.2.0 integrated C-based PAVA for isotonic regression.
		Version 1.1.0 introduced conservative MTD selection (boundMTD)
		and flexible early stopping rules (n_earlystop_rule). Methods
		are described in Liu and Yuan (2015) doi:10.1111/rssc.12089.
	</longdescription>
</pkgmetadata>
